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doi: 10.3389/fphar.2022.838133 Received 17 December 2021 Accepted 03 February 2022 Published 25 February 2022 Volume 13 - 2022 Edited by Domenico Ribatti, University of Bari Aldo Moro, Italy Reviewed by Benedetta Bussolati, University of Turin, Italy Lasse Dahl Ejby Jensen, Linkping University, Sweden Antonio Giovanni Solimando, University of Bari Aldo Moro, Italy Updates Copyright 2022 Ayoub, Jaradat, Al-Shami and Alkhalifa